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TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂,可用于治疗 HCV 感染。它具有纳摩尔级细胞效力(EC(50) 为 82 nM),相关细胞毒性较小(CC(50)>20 μM),在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
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TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂,可用于治疗 HCV 感染。它具有纳摩尔级细胞效力(EC(50) 为 82 nM),相关细胞毒性较小(CC(50)>20 μM),在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 996 | 现货 | |
5 mg | ¥ 2,160 | 现货 | |
10 mg | ¥ 2,990 | 现货 | |
25 mg | ¥ 4,950 | 现货 | |
50 mg | ¥ 6,910 | 现货 | |
100 mg | ¥ 9,490 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,850 | 现货 |
产品描述 | TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation. |
别名 | TMC647055 Choline Hydroxide Salt (1204416-97-6 free base) |
分子量 | 727.91 |
分子式 | C37H53N5O8S |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/ml (82.43 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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